Department of Growth and Development, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH
(Received 17 June 1974)
Although somatomedin (SM) is established as the hormone through which growth hormone (GH) affects bone growth (Daughaday, 1971), the organ that produces it is not yet known (Van Wyk, Underwood, Lister & Marshall, 1973). McConaghey & Sledge (1970) showed that the addition of bovine GH to perfusion fluids passing through the liver led to an increase of sulphation factor (incorporation of thymidine was not examined) but this was measured only with a 2-point assay. Hintz, Clemmons & Van Wyk (1972) produced apparent sulphation factor activity by superfusion of liver slices with media containing human GH but the dose–response curves were not parallel to those produced by plasma. SM activity has been reported from perfused kidneys (McConaghey & Dehnel, 1972) and from muscle (Hall, Holmgren & Lindahl, 1970).
Rats were perfused using
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
