University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria 3084 and Monash University, Department of Medicine, Prince Henry's Hospital, St Kilda Road, Melbourne, Victoria 3004, Australia
(Received 25 February 1974)
The present studies were made on the function of the placenta and foetal adrenals in an oophorectomized and adrenalectomized woman during the second trimester of pregnancy. Bilateral oophorectomy at week 9 of pregnancy and bilateral adrenalectomy at week 14 of pregnancy were carried out for multiple breast cancer metastases. Unfortunately, at the time, the possibility of pregnancy was not excluded. Replacement treatment was started and continued with cortisol (20 mg/day).
Oestrone, oestradiol and oestriol were measured by the method of Brown (1955) and colorimetrie estimation and correction for loss were done as previously described (Maeyama, Nakagawa, Tuchida & Matuoka, 1969). Pregnanediol was measured by g.l.c. Urinary 17-hydroxycorticosteroids (17-OHCS) were measured by a modification of the method of Silber &
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