Department of Medicine and Biochemistry Research Group, University of Otago Medical School, Dunedin, New Zealand
(Received 7 October 1974)
High doses of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) inhibit bone mineralization, induce hypercalcaemia and diminish intestinal absorption of calcium in the rat (Gasser, Morgan, Fleisch & Richelle, 1973; Goulding & McChesney, 1974). This hypercalcaemia, either by a direct effect or by inhibiting secretion of parathyroid hormone (PTH), may suppress renal synthesis of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) and hence explain the diminished intestinal absorption of calcium (Bonjour, DeLuca, Fleisch, Trechsel, Matejowee & Omdahl, 1973; Hill, Lumb, Mawer & Stanbury, 1973). Parathyroid hormone affects the renal production and excretion of cyclic AMP (Chase & Aurbach, 1967) and cyclic AMP enhances the synthesis of 1,25(OH)2D3 (Rasmussen, Wong, Bikle & Goodman, 1972; Larkins, MacAuley, Rapoport, Martin, Tullock, Byfield, Matthews & Maclntyre, 1974). Thus reduced production of cyclic AMP after administration of EHDP may be important in diminishing renal synthesis
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