MODIFICATION OF MYOMETRIAL ACTIVITY IN VIVO BY ADMINISTRATION OF CYCLIC NUCLEOTIDES AND THEOPHYLLINE TO THE PREGNANT RAT

in Journal of Endocrinology
Authors:
J. W. BUCKLE
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P. W. NATHANIELSZ
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SUMMARY

Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short-term infusions of theophylline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were investigated. All three compounds caused a decrease in oxytocin-induced, prostaglandin F-induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre-infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.

 

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