Hospital Alvarez, Aranguren 2701, Buenos Aires, Argentina
(Received 12 February 1975)
Sulpiride, N-(1-ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulphamoylbenzamide, was synthesized in 1961 and was demonstrated to have pharmacological effects similar to those of chlorpromazine (Justin-Besacon, Thominet, Laville & Margarit, 1967). Recently we, as well as other investigators, reported that patients under treatment with sulpiride very often had galactorrhoea and in some cases also amenorrhoea (Mancini, Guitelman, Molocznik, Banchik, Laszlo, Fideleff, Artese & Martinez Montes, 1972; Netter, Gorins, Franchimont & Mullet, 1972).
In view of these findings, it was decided to study the effects of treatment with sulphide on serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in a group of patients with increased basal serum concentrations of gonadotrophin such as postmenopausal women.
Ten menopausal women, aged between 42 and 58 years, were studied. The shortest period with amenorrhoea was 8 months and the most prolonged was 10 years. All the patients had the typical
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
