Department of Chemical Pathology, St. Bartholomew's Hospital, London, EC1A 7BE
(Received 17 January 1975)
PAGE
Glossary of abbreviations 143
Introduction 143
Classification 144
Evidence for the secretion of hormones by non-endocrine tumours 145
Incidence 147
Processes of formation and release of ectopic hormones 149
Ectopic hormone secretion 151
(1) Adrenocorticotrophin/lipotrophic hormone/melanocyte-stimulating hormone 151
(2) Non-metastatic hypercalcaemia 155
(3) Antidiuretic hormone, oxytocin, neurophysin 157
(4) Gonadotrophins 159
(5) Human placental lactogen 159
(6) Growth hormone 159
(7) Insulin 160
(8) Calcitonin 162
(9) Thyroid-stimulating hormone 162
(10) Prolactin 162
(11) Erythropoietin 163
(12) Gut hormones 163
(13) Hypophosphataemic osteomalacia 163
(14) Multiple ectopic hormone secretion 163
Ectopic hormones as tumour-indexing substances 164
Postulated mechanisms of ectopic hormone secretion 165
Conclusions 167
References 167
ACTH Adrenocorticotrophin
ADH Antidiuretic hormone
APUD Amine precursor uptake and decarboxylation
AVP Arginine vasopressin
CLIP Corticotrophin-like intermediate lobe peptide
5-HT Serotonin
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