Testosterone metabolism was studied in tissues associated with a keratin-filled cutaneous cyst. Instead of the 5α-reduced metabolites usually associated with skin steroid metabolism, considerable amounts of 5β-reduced steroids were found. These included 5β-androstane-3,17-dione, 17β-hydroxy-5β-androstan-3-one, and 5β-androstane-3β,17β-diol. This change in metabolic pattern is discussed.
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