The effect of doses of oestradiol ranging from 0·0125 to 1·6 μg on the uterine weight of the spayed rat was studied 24 h after a single s.c. injection of the hormone. The lowest dose inducing a significant increase in uterine weight was 0·32 μg. When histamine dihydrochloride (50 mg) was simultaneously injected with the hormone, the effect of small doses of oestradiol (0·0125–0·2 μg) was significantly increased.
When oestradiol and histamine were administered for 3 successive days, the uterine weight of animals receiving 0·0125 μg oestradiol, if compared with untreated controls, was increased only in the histamine-treated group. When 0·05 μg oestradiol was administered, histamine did not modify the increase already produced by the hormone.
Spermidine and burimamide, two substances structurally related to histamine, increased [3H]oestradiol uptake by the spayed rat uterus. The latter (an antihistamine drug acting on H2-receptors) as well as pyrathiazine (a histamine releaser having antihistamine properties) decreased the effect of histamine on oestradiol uptake whereas diphenhydramine (an antihistamine drug blocking H1-receptors) did not modify it. Pyrathiazine was itself able to diminish oestradiol uptake.
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