Department of Pure and Applied Zoology, The University, Leeds, LS2 9JT
(Received 17 July 1975)
The tetradecapeptide growth hormone inhibiting factor (GIF), synthesized by Coy, Coy, Arimura & Schally (1973) and Rivier, Brazeau, Vale, Ling, Burgus, Gilon, Yardley & Guillemin (1973), is reported to inhibit growth hormone (GH) secretion in mammals both in vitro and in vivo. It reduces the basal serum GH levels in rats (Brazeau, Rivier, Vale & Guillemin, 1974) and also inhibits the basal release of GH from rat pituitary cells incubated in vitro (Grant, Sarantakis & Yardley, 1974). Growth hormone inhibiting factor abolishes the suckling-induced rise in plasma GH levels in rats (Chen, Mueller & Meites, 1974) and similarly reduces the l-DOPA-stimulated rise in plasma GH in dogs (Lovinger, Boryczka, Shackleford, Kaplan, Ganong & Grumbach, 1974). In man, GIF reduces the serum GH levels artificially raised by means of insulin-induced hypoglycaemia (Schally, Coy, Kastin, Tunbridge, Evered,
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