Biology Department, University of Zambia, P.O. Box 2379, Lusaka, Zambia
(Received 18 July 1975)
Traumatization makes the uterus of ovariectomized rats sensitive to exogenous prolactin (Joseph & Mubako, 1975). The presence of intra-uterine devices induces uterine hypertrophy and concurrently increases the production of prostaglandin F (Lau, Saksena & Chang, 1974; Saksena & Harper, 1974). In another recent report prolactin has been shown to stimulate the synthesis of prostaglandin-like material in the rat mesentery (Horrobin, Manku, Karmazi, Nassar & Greaves, 1974). Pharris & Hunter (1971) have demonstrated that prostaglandin F2α could enhance the uterine growth promoting effect of pregnant mare serum gonadotrophin in the immature rat. All this evidence led Joseph & Mubako (1975) to conclude that prostaglandins might be involved in the extra-ovarian stimulatory effect of prolactin on the traumatized uterus in the rat. The study reported here was carried out to determine whether prostaglandin F2α could imitate, or synergise
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