Instituto de Investigaciones Cerebrales, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina
(Received 12 August 1975)
There is recent evidence that histamine is a normal constituent of the brain (Taylor, Gfeller & Snyder, 1972; Brownstein, Saavedra, Palkovitz & Axelrod, 1974) localized in nerve terminals and synaptic vesicles (Kataoka & De Robertis, 1967). As reported earlier, intracerebral injections of histamine induce ovulation (Sawyer, 1955) and progesterone secretion (Endröczi & Hilliard, 1965) in rabbits. Moreover histamine administration results in oviposition in fishes (Nambu & Hosokawa, 1971). These results suggest that histamine leads to increased gonadotrophic activity and thus its potential role as a neuroendocrine transmitter is being investigated. In the present preliminary investigation histamine was injected into the 3rd ventricle of adult (250–300 g body wt) male and female rats derived from a Holtzman stock. They were maintained in a room with controlled temperature (23 ± 1 °C) and lighting
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