Department of Physiology, Royal Veterinary College, London, NW1 OTU
(Received 21 August 1975)
19-Hydroxytestosterone (17β-hydroxy-4-androsten-19-ol-3-one; 19HT) and its 5α-reduced metabolite (17β-hydroxy-5α-androstan-19-ol-3-one; 5α-19HT)have negligible stimulatory effects on androgen target organs in the castrated rat (Parrott, 1974, 1975). The object of this study was to establish whether these androgens can limit the release of luteinizing hormone (LH) from the pituitary. To investigate this they were compared with testosterone for their ability to prevent compensatory ovarian hypertrophy in the unilaterally ovariectomized rat.
Forty-eight adult female Sprague-Dawley (MRC) rats were hemi-ovariectomized and allocated to six groups of eight animals each. Body weights and the weight of the left ovary were recorded. Starting from ovariectomy, rats received ten daily 0·2 ml s.c. injections after which they were killed. Treatments were oil vehicle (control); testosterone, 1 mg/day; 19HT, 1 mg/day; 19HT, 2 mg/day; 5α-19HT, 1 mg/day; 5α-19HT, 2 mg/day. All solutions were kept on a hotplate
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 0 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
