INHIBITION BY OESTRADIOL OF THE PITUITARY RESPONSE TO LUTEINIZING HORMONE RELEASING HORMONE IN THE DOG

in Journal of Endocrinology
Authors:
GWYNETH E. JONES
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A. R. BOYNS
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SUMMARY

Intravenous injections of synthetic LH-RH stimulated LH secretion in male dogs. Pretreatment with 50 μg oestradiol-17β, 60 or 165 min but not 15 min before LH-RH, inhibited LH secretion. Injection of 0·1–10 μg oestradiol 165 min before administration of LH-RH, blocked LH secretion. Basal plasma LH levels before LH-RH administration were lower in dogs given oestradiol than in controls.

 

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