Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, U.S.A.
(Received 21 August 1975)
Although increase of plasma free fatty acids (FFA) follows growth hormone (GH) treatment in all mammalian species tested (Goodman & Schwartz, 1974), the manner in which the hormone stimulates lipolysis is not known. The delay of at least 2 h between GH administration and the onset of the lipolytic response, coupled with difficulty in demonstrating this effect of GH in vitro, suggests that intermediate events may occur. Wallace and his colleagues (1969, 1972) found that, in sheep, labelled GH was immunologically modified in passing through the kidney. Renal ablation immediately before the administration of GH blunted the increase in blood concentrations of FFA which normally occurs when GH is given to intact sheep (Wallace, Stacy & Thorburn, 1970). These findings suggest that the kidney may produce, possibly from GH itself, a mediator of the
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