GASTROINTESTINAL HORMONES

in Journal of Endocrinology
Authors:
E. J. W. BARRINGTON
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G. J. DOCKRAY
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*Department of Zoology, University of Nottingham, and †Department of Physiology, University of Liverpool, Liverpool, L69 3BX

(Received 8 August 1975)

CONTENTS

Page

Introduction 299

Gastrin and cholecystokinin 300

Chemistry of gastrin 300

Chemistry of cholecystokinin 302

Phylogenetic relationships between CCK and gastrin 302

Caerulein 303

Structure-activity relationships 303

Physiological actions 304

Metabolism 305

Regulation of secretion 306

Page

Secretin-glucagon family 306

Chemistry 306

Phylogenetic relationships 307

Biological actions 308

Structure-activity relationships 309

Regulation of secretion 310

Functional interactions 310

The sources of the hormones 313

Characterization of cell types 314

The APUD concept 316

The lower vertebrates and the protochordates 316

References 318

INTRODUCTION

The discovery by Bayliss & Starling (1902) of the hormonal regulation of pancreatic secretion has rightly been regarded as a major landmark in the development of endocrinology, yet for many years thereafter the study of gastrointestinal hormones was unduly neglected, except in

 

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