Department of Physiology, Royal Veterinary College, Royal College Street, London, NW1 OTU
(Received 19 February 1976)
Administration of testosterone to newborn female rats suppresses cyclic gonadotrophin secretion and sexual receptivity in adulthood (Barraclough, 1961). This effect probably depends upon the conversion of testosterone to oestrogen in the brain (Reddy, Naftolin & Ryan, 1974; Doughty, Booth, McDonald & Parrott, 1975). Hydroxylation of the androgen molecule at carbon-19 is the initial step in aromatization (Gual, Morato, Hayano, Gut & Dorfman, 1962), and injecting 19-hydroxytestosterone (17β-hydroxy-4-androsten-19-ol-3-one; 19HT) into neonatal female rats prevents cyclic ovulation in adulthood (McDonald & Doughty, 1974). On the other hand, 5α-reduction of testosterone blocks conversion to oestrogen as the product, dihydrotestosterone (17β-hydroxy-5α-androstan-3-one; DHT), cannot be aromatized. Since DHT does not affect sexual differentiation of the brain (McDonald & Doughty, 1974), the non-aromatizable 5α-reduced form of 19HT (17β-hydroxy-5α-androstan-19-ol-3-one; 5α-19HT) should similarly be ineffective. This study compares the defeminization induced in
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 1 | 0 |
| PDF Downloads | 1 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
