Division of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
(Received 26 February 1976)
The production of highly specific antisera to oxytocin and vasopressin for radioimmunoassay was only recently achieved (Chard, 1973). Two major difficulties encountered in the attempts at production of antisera to these hormones have been: first, that both hormones have low molecular weights (approximately 1000); and secondly, they are usually native to the animals being immunized, although [Arg8]-vasopressin (AVP) has been successfully used for the production of antisera in rabbits. The molecular weights can be augmented by covalently coupling the hormones, before immunization, to large molecular weight ligands such as thyroglobulin (Skowsky & Fisher, 1972; Chard, 1973). [8-Lysine]-vasopressin (LVP), which is found in suiformes, is closely related chemically and biologically to AVP - the vasopressin of most mammals. Lysine-vasopressin has been used successfully for the production of antisera for radioimmunoassays (Skowsky,
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