SEX HORMONE PRODUCTION BY ISOLATED RABBIT FOLLICLES IN THE PRESENCE OF GONADOTROPHINS

in Journal of Endocrinology
Author:
E. V. YOUNGLAI
Search for other papers by E. V. YOUNGLAI in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

Department of Obstetrics and Gynecology, Programme in Reproductive Biology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada, L8S 4J9

(Received 23 April 1976)

In a previous communication it was observed that luteinizing hormone (LH) (10 μg/ml) had no effect on oestradiol production by rabbit follicles while testosterone production was greatly increased (YoungLai, 1974). In the same study lower concentrations of LH (1 and 10 ng/ml) appeared to stimulate oestrogen secretion. Whereas Mills, Davies & Savard (1971) showed that the rabbit follicle is extremely sensitive to LH, with good incorporation of [14C] acetate to oestrogens, Moor (1974) demonstrated that high levels of LH inhibit aromatization in sheep follicles. On the other hand, Ryle, Court, Smith & Morris (1975) found that immature mouse ovaries can produce oestrogen in the presence of LH and follicle-stimulating hormone (FSH), alone and in combination. Equine granulosa cells can aromatize testosterone to oestrogens in the presence of

 

  • Collapse
  • Expand