Department of Obstetrics and Gynaecology, University of Sydney, NS. W. 2006, Australia
(Received 13 July 1976)
Prostaglandin F2α(PGF2α) secreted from the uterus exerts a luteolytic effect on the corpus luteum in a number of species of non-pregnant mammals (see review of Labhsetwar, 1974). This luteolytic mechanism has not been demonstrated in non-pregnant women (Lyneham, Korda, Shutt, Smith & Shearman, 1975). Nor were Leader, Bygdeman, Cekan, Diczfalusy, Guerrero, Martin & Wiqvist (1975) able to demonstrate an accelerative effect of intra-uterine 15 (S) 15-methyl PGF2α or an inhibitory effect of oral indomethacin on post-abortion luteolysis in women in early pregnancy. The presence of PGF2α receptors however, in human corpora lutea (Powell, Hammarström, Samuelsson & Sjöberg, 1974) suggested the possibility of a local production of PGF2α within the ovary being responsible for luteolysis in women, and Korda, Shutt, Smith, Shearman & Lyneham (1975) were able to obtain a transient luteolysis when 0·5–1·0 mg
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