A POSSIBLE INTERRELATIONSHIP BETWEEN GONADOTROPHIN STIMULATION AND PROSTAGLANDIN F2α INHIBITION OF STEROIDOGENESIS BY GRANULOSA-LUTEAL CELLS IN VITRO

in Journal of Endocrinology
Authors:
K. M. HENDERSON
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and
K. P. McNATTY
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DOI:
https://doi.org/10.1677/joe.0.0730071
Volume/Issue:
Volume 73: Issue 1
Article Type:
Research Article
Page Range:
71–78
Online Publication Date:
Apr 1977
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SUMMARY

The newly formed corpus luteum of many species is refractory to the lytic action of prostaglandin F2α (PGF2α). This phenomenon was studied utilizing porcine, bovine and human granulosa-luteal cells in tissue culture. The steroidogenic potential of the granulosa-luteal cells was critical in determining whether PGF2α could inhibit progesterone production. Since the steroidogenic potential of the granulosa-luteal cell is related to the amount of LH bound to the cell, the bound LH may protect the granulosa-luteal cells from the lytic action of PGF2α. Finally, a 'see-saw' type of interaction between LH and PGF2α is postulated to account for the resistance of the newly formed corpus luteum to PGF2α

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
8
Article Type:
Research Article
Print Publication Date:
01 Jan 1977
Online Publication Date:
Apr 1977