A POSSIBLE INTERRELATIONSHIP BETWEEN GONADOTROPHIN STIMULATION AND PROSTAGLANDIN F INHIBITION OF STEROIDOGENESIS BY GRANULOSA-LUTEAL CELLS IN VITRO

in Journal of Endocrinology
Restricted access

SUMMARY

The newly formed corpus luteum of many species is refractory to the lytic action of prostaglandin F (PGF). This phenomenon was studied utilizing porcine, bovine and human granulosa-luteal cells in tissue culture. The steroidogenic potential of the granulosa-luteal cells was critical in determining whether PGF could inhibit progesterone production. Since the steroidogenic potential of the granulosa-luteal cell is related to the amount of LH bound to the cell, the bound LH may protect the granulosa-luteal cells from the lytic action of PGF. Finally, a 'see-saw' type of interaction between LH and PGF is postulated to account for the resistance of the newly formed corpus luteum to PGF

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 72 38 2
Full Text Views 44 1 0
PDF Downloads 68 0 0