Cátedra de Fisiología con Biofísica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60y 120, 1900 La Plata, Argentina
(Received 23 July 1976)
There is general agreement that glucose-induced insulin release is mediated by a complex mechanism (Randle & Hales, 1972). It has also been postulated that cyclic AMP might play an important role in this process. However, conflicting results have been reported about the effect of glucose on cyclic AMP levels in the islets of Langerhans (Charles, Fanska, Schmid, Forsham & Grodsky, 1973; Cooper, Ashcroft & Randle, 1973). Since it has been shown that cyclic AMP release from the liver rather than its intracellular concentration is better related to some metabolic effects (Exton & Park, 1972), we felt that a similar correlation might exist in the β cell. The release of both insulin and cyclic AMP by isolated islets was measured in the presence of various glucose concentrations.
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