Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183, Japan
(Received 2 May 1977)
When an amount of human chorionic gonadotrophin (HCG) sufficient to cause ovulation is given to 4-day cyclic rats on the day of dioestrus, premature ovulation is induced the next morning (Eto & Imamichi, 1955). The pattern of release of follicle-stimulating hormone (FSH) responsible for the initiation of follicular maturation of the next set of follicles (Schwartz, 1969; Welschen & Dullaart, 1976) after HCG-induced ovulation has not been previously evaluated. The present communication is concerned with this problem and indicates that a large amount of FSH is released within 12 h of administration of HCG, with only a small concomitant rise in the concentration of luteinizing hormone (LH).
Adult female Wistar rats were maintained under a 14 h light : 10 h darkness schedule (lights on 05.00 h), and those showing three or
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