WHO Clinical Research Centre on Human Reproduction, University Medical School of Szeged, Hungary
(Received 14 July 1977)
Jarabak (1972), Keirse, Flint & Turnbull (1974) and Schlegel, Demers, Hildebrandt-Stark, Behrman & Greep (1974) demonstrated that the human placenta at term is very rich in enzymes involved in prostaglandin (PG) metabolism. Our previous investigations (Falkay & Sas, 1976) showed that even the early human placenta inactivates PG very rapidly and that the major site of metabolism in the foetal-placental unit is the placenta. It is possible that PG metabolism by the placenta stops the development of spontaneous uterine contractions.
Carminati, Luzziani, Soffientini & Lerner (1975) investigated 15α-hydroxy-prostaglandin dehydrogenase (15-OH-PGDH) activity in the rat placenta during pregnancy and observed a significant relationship between the day of pregnancy and PG synthesis and metabolism. The investigations of Alam, Rüssel & Moulton (1976) in the rat also suggest that 15-OH-PGDH activity is under hormonal control.
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