RELEASE OF LUTEINIZING HORMONE IN ANDROGENIZED EWES AFTER PROSTAGLANDIN-INDUCED LUTEOLYSIS OR LUTEINIZING HORMONE RELEASING HORMONE

in Journal of Endocrinology
Authors:
I. J. CLARKE
Search for other papers by I. J. CLARKE in
Current site
Google Scholar
PubMed
Close
and
R. J. SCARAMUZZI
Search for other papers by R. J. SCARAMUZZI in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

M.R.C. Unit of Reproductive Biology, 2 Forrest Road, Edinburgh, EHI 2QW

(Received 31 October 1977)

Exposure to testosterone during development masculinizes the genitalia and behaviour of ewes (Clarke, Scaramuzzi & Short, 1976a; Clarke, 1977) and causes ovulatory failure (Clarke, Scaramuzzi & Short, 1977). Androgenized ewes do not release luteinizing hormone (LH) after oestrogen treatment during anoestrus (Clarke, Scaramuzzi & Short, 1976b). These experiments were performed to determine the site of action (hypothalamus or anterior pituitary gland) of prenatally administered androgens in blocking the preovulatory release of LH.

Finnish Landrace × Dorset Horn ewes were used in their second breeding season after exposure to testosterone between days 30 and 80 (D30–80, n = 6), 50 and 100 (D50–100, n = 1), 70 and 120 (D70–120, n = 6) or 90 and 140 (D90–140, n = 5) of prenatal life (Clarke et al. 1976a). Eight normal ewes served as controls. To facilitate

 

  • Collapse
  • Expand