Biophysical Endocrinology Unit, Department of Physics as Applied to Medicine, Middlesex Hospital Medical School, London, W1P 6DB
(Received 6 February 1978)
Steroid secretion by the zona glomerulosa is extremely sensitive to changes in the extracellular concentration of potassium ions ([K+]). The manner in which a change in [K+] is transmitted to the steroidogenic mechanism is not known, but recent data have shown that the flux of 45Ca2+ is altered during such stimulation (Mackie, Warren & Simpson, 1978). More detailed information concerning ion and hormone dynamics during stimulation may be obtained from studies involving the superfusion of dispersed cells.
The 'centrifuge' procedure (Schulster & Jenner, 1975) could not be applied successfully to zona glomerulosa cells; during the first 15 min 50% of the cells were lost, with a subsequent loss of 10% of the original number of cells/h. Thus the alternative 'cell-column' procedure (Lowry & McMartin, 1974) was evaluated and two
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 3 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
