Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia
(Received 14 March 1978)
Administration of adrenocorticotrophin (ACTH; 80–100 i.u./day) to conscious trained sheep for 5 days produces a significant rise in blood pressure within 24 h which is maintained over a 5 day period of treatment. The increase in blood pressure is accompanied by an increase in cardiac rate, hypokalaemia, hypernatraemia and, initially, urinary retention of sodium; subsequently there is a natriuresis and an increase in both water intake and urine output (Scoggins, Coghlan, Denton, Fan, McDougall, Oddie & Shulkes, 1974). During the last third of gestation, the response to intravenous angiotensin II in the ewe is depressed to about 15% of the response observed in non-pregnant animals, but is not reduced further by sodium deficiency (Blair-West, Coghlan, Denton, Scoggins & Wintour, 1972); pregnant ewes can, however, be made hypertensive by constriction of the
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