Three groups of twelve guinea-pigs were selected from a batch inoculated with a live culture of BCG. Two of these groups were selected for treatment with thyroxine and thiouracil. The third served as untreated controls. The experiment was divided into three periods; in the first, groups I and III received thyroxine and thiouracil respectively; in the second, all drug treatment was discontinued; in the third, the treatments were reversed, thiouracil being given to group I and thyroxine to group III. All guinea-pigs were injected intradermally with OT and PPD tuberculins at the end of the first and third periods; the diameters of the 24 hr. lesions were analysed by the appropriate statistical methods.
Thyroxine and thiouracil had opposite effects on the reactions to PPD tuberculin, the former depressing the average response. Effects on the reactions to OT were irregular. There were no significant effects on the fresh weights of the adrenal glands.
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