To assess the renin–aldosterone system in a large mammal, simultaneous morning activities of plasma renin and concentrations of aldosterone and cortisol were measured in 25 thoroughbred horses. Renin was relatively low in all horses (0·16±0·02 (s.e.m.) ng angiotensin I/ml per h), levels of aldosterone in plasma were 527±130 pmol/l and levels of cortisol in plasma were 141±11 nmol/l. Levels of aldosterone were significantly correlated with levels of renin in all horses (r = 0·62, P < 0·001) but not with those of cortisol, and renin was negatively correlated with age in male horses (r = −0·54. P < 0·05). Horse plasma renin had a pH optimum of 6·0.
These data suggest that the thoroughbred horse has a functioning renin–aldosterone system characterized by levels of plasma renin activity that are much lower relative to those of other mammalian species.
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