ROLE OF THE MEDICAL–BASAL HYPOTHALAMUS IN THE SECRETION OF GROWTH HORMONE DURING PREGNANCY AND LACTATION IN EWES

in Journal of Endocrinology
Authors:
BARBARA WRÓBLEWSKA
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E. DOMAŃSKI
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DOI:
https://doi.org/10.1677/joe.0.0890349
Volume/Issue:
Volume 89: Issue 3
Article Type:
Research Article
Page Range:
349–354
Online Publication Date:
Jun 1981
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The main aim of this study was to examine the role of the hypothalamus in controlling the secretion of GH in the ewe. This was evaluated by studying the effect of lesions placed either in the anterior or the posterior medial–basal hypothalamus (MBH) on the concentration of GH in the peripheral circulation during pregnancy and lactation, i.e. when the levels would be high in normal ewes. Simultaneously, the level of prolactin in the peripheral blood of these animals was followed. Lesions of the MBH resulted in a marked decrease in circulating GH as well as disturbances in the mammogenic and lactogenic processes during the periods of periparturition and lactation respectively. The changes were particularly evident if the anterior MBH was lesioned. The present experiments confirm our previous findings that a stimulatory centre is localized in the anterior MBH of sheep whilst in the caudal MBH there is an inhibitory centre regulating the release of prolactin. The results also confirm the important role of GH during lactation in ewes, especially during lactogenesis. The results indicate a differentiated but synchronizing and synergistic role of the MBH regulating the patterns of GH and prolactin secretion in late pregnancy and lactation.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
6
Article Type:
Research Article
Print Publication Date:
01 Jun 1981
Online Publication Date:
Jun 1981