A method for estimating thyroidal clearance of radioiodide from the blood plasma of the domestic fowl is described. It differed from published methods in a number of ways. (1) It utilized total thyroidal radioiodide concentration (IT) and did not require the use of goitrogens or the separation of free and protein-bound components. (2) Radioiodide was injected intravenously rather than by other routes. (3) Plasma radioiodide concentration (IB) was determined from several serial samples from each bird rather than once only. (4) The method allowed the clearance constant (α; μl/min per mg) to be estimated for individual birds, rather than from groups, thereby enabling effective replication for comparative experiments. The constant was estimated from the model dIT/dt = αIB, measurements being made within 120 min after injection to ensure that exit of radioiodide from the thyroid was negligible. The improved method resulted in estimates of clearance constants which agreed well with published findings.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 2 | 0 | 0 |
| PDF Downloads | 1 | 1 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
