Treatment of adult male mice with varying doses of prolactin increased the weights of the seminal vesicles and the anterior prostate gland. Only in the seminal vesicles were these increases in organ weights associated with increased levels of DNA. In castrated mice, prolactin alone failed to alter the weights of the accessory sex organs or DNA content. However, the simultaneous administration of prolactin and testosterone resulted in enhanced androgenic stimulation of seminal vesicle weights and their DNA content. Prostatic weights, but not DNA content, were augmented by treatment with prolactin and testosterone. Although the kidneys exhibited androgen sensitivity, prolactin failed to enhance the effect of testosterone upon the kidney. Augmentation of androgen action in the accessory sex organs was observed only after treatment with prolactin or growth hormone. Prolactin also enhanced the effects of dihydrotestosterone and 5α-androstane-3α, 17β-diol, but not of 5α-androstane-3β,17β-diol.
These studies revealed that prolactin enhances the proliferative actions of androgens in mouse seminal vesicles, but not in the anterior prostate glands or the kidneys.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
