Treatment of adult male rats with oestradiol-17β (50 μg/100g body wt per day for 7 days) resulted 14 days later in reduced levels of α2u-globulin in serum and inhibition of spermatogenesis. Administration of corticosterone (2 mg/day) for 14 days to oestrogen-treated rats raised the concentration of α2u-globulin in the serum and prevented spermatogenic degeneration. It is concluded that endogenous α2u-globulin induced by corticosterone may play a role in spermatogenesis in oestrogenized rats.
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