The effects of oestradiol-17β and/or hypophysectomy on the metabolism of benzo(a)pyrene (BP), paranitroanisole (PNA), ethylmorphine (EM) and 7-ethoxycoumarin by liver microsomes from juvenile rainbow trout, Salmo gairdnerii, were studied. Administration of oestradiol-17β caused significant decrease in the liver microsomal metabolism of BP, PNA and EM while hypophysectomy had no effect. The suppressive effect of oestradiol-17β on the mixed function oxidases was as pronounced in hypophysectomized as in sham-operated fish, indicating that this effect of oestradiol-17β is mainly direct and independent of the pituitary gland. Administration of oestradiol-17β caused a significant increase in the apparent Km values of the PNA-O-demethylase whereas no alteration was seen in the apparent Vmax values of the enzyme. The results indicate that oestradiol-17β may play a role in the regulation of hepatic mixed function oxidases in rainbow trout.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 1 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
