Utilizing the difference in pH optima between two distinct enzyme systems responsible for the thyroxine (T4) inner and outer ring monodeiodination, and a specific radioimmunoassay for iodothyronines, the net T4 conversion to 3,3′,5′-tri-iodothyronine (rT3) and 3,5,3′-tri-iodothyronine (T3) in growing pigs kept under various food restrictions was determined in vitro. It has been found that fasting lowers deiodination of T4 to T3 by liver and kidney homogenates. The conversion of T4 to rT3 was reduced in the liver but not in the kidney, unless the animals were completely fasted. During food restriction serum T4 and T3 decreased whereas rT3 increased, which indicated that the serum rT3 level is not a good reflection of T4 to rT3 converting activity in the liver or kidney. The data suggest that a rise in rT3 reflects a lowered degradation rate of the hormone or an increased secretion by the thyroid gland rather than changes in rT3 neogenesis in the periphery.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
