Minces of the prostate and seminal vesicles of the mature boar were incubated with the following major testicular steroids of the pig: [3H]dehydroepiandrosterone, [3H]5-androstene-3β,17β-diol, [3H]oestrone, [3H]oestradiol-17β and their respective sulphate conjugates (excluding oestradiol-17β). Incubations were also carried out with [3H]testosterone, [3H]5α-dihydrotestosterone and [3H]5α-androstanediols. Minces of the epididymides were incubated with [3H]dehydroepiandrosterone and [3H]oestrone sulphates. The prostate and seminal vesicles converted dehydroepiandrosterone predominantly to weak androgens, whereas 5-androstene-3β,17β-diol was primarily converted to testosterone; testosterone and its 5α-reduced metabolites were metabolized in a manner typical of androgen end target organs. Unconjugated oestrone and oestradiol-17β were interconverted by the prostate and seminal vesicles. The metabolism of C19 steroid sulphates was < 1% in all incubations; some oestrone sulphate, however, was converted to unconjugated oestrone and oestradiol, particularly by the caput epididymidis. The significance of these results is discussed in relation to recent studies in vivo.
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