Testosterone metabolism was studied in vitro in the prostate of intact and castrated golden hamsters maintained either in short days (8 h light: 16 h darkness, 8L : 16D) or in long days (14L : 10D). Testosterone was found to be converted into 17β-hydroxy-5α-androstan-3-one (5α-DHT), 5α-androstane-3α, 17β-diol, 5α-androstane-3, 17-dione and androstenedione. The mean conversion of testosterone to 5α-DHT was higher in prostates from animals maintained in long days than in short days (P < 0·0025) while that to androstenedione was higher in short days (P <0·0005); no significant changes in the formation of the other three metabolites were noted. Castration of animals maintained in short days resulted in a significant (P <0·05) decrease in the mean conversion to all four metabolites. In contrast, castration of animals kept in a long-day regime caused a significant (P <0·01) decrease in the mean formation of 5α-DHT but a significant (P <0·05) increase in the mean formation of 5α-androstane-3α, 17β-diol.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
Sept 2018 onwards | Past Year | Past 30 Days | |
---|---|---|---|
Full Text Views | 2 | 0 | 0 |
PDF Downloads | 3 | 0 | 0 |