Participation of the intermediate lobe of the pituitary gland after prolonged exposure to unpredictable stress in the rat

in Journal of Endocrinology
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An ultrastructural study is described which relates cellular activity in the intermediate lobe of the pituitary gland with circulating levels of corticosterone. Exposure of male CSF rats to a signalled, unpredictable 60-day stress regimen induced intense secretory activity in all cells of the pars intermedia for the first 5 days of stressing, and thereafter secretory activity reverted back to the control condition. Blood corticosterone levels showed an initial extreme increase lasting for the first 5 days of exposure to the stress before gradually falling to re-establish a new stable level of secretion by 40 days. The possible involvement of the intermediate lobe in emotional or psychological stress when corticosterone levels are high is discussed.

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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