Tissue selective effects of bazedoxifene on the musculoskeletal system in female mice

in Journal of Endocrinology
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  • 1 C Cabelka, Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota Medical School Twin Cities, Minneapolis, United States
  • 2 C Baumann, Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota Medical School Twin Cities, Minneapolis, United States
  • 3 A Lindsay, Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota Medical School Twin Cities, Minneapolis, United States
  • 4 A Norton, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, United States
  • 5 N Blixt, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, United States
  • 6 G Le, Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota Medical School Twin Cities, Minneapolis, United States
  • 7 G Warren, 6Department of Physical Therapy, Georgia State University, Atlanta, 30302-3965, United States
  • 8 K Mansky, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, United States
  • 9 S Novotny, Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota Medical School Twin Cities, Minneapolis, United States
  • 10 D Lowe, Department of Rehabilitation Medicine, University of Minnesota Medical Center, Minneapolis, United States

Correspondence: Dawn A. Lowe, Email: lowex017@umn.edu

The actions of selective estrogen receptor modulators are tissue dependent. The primary objective of the current study was to determine the tissue selective effects of bazedoxifene (BZA) on the musculoskeletal system of ovariectomized (OVX) female mice, focusing on strengths of muscle-bone pairs in the lower hindlimb. Treatment with BZA after ovariectomy (OVX+BZA) did not prevent body or fat mass gains (p<0.05). In vivo plantarflexor muscle isometric torque was not affected by treatment with BZA (p=0.522). Soleus muscle peak isometric, concentric and eccentric tetanic force production were greater in OVX+BZA mice compared to OVX+E2 mice (p≤0.048) with no effect on maximal isometric specific force (p=0.228). Tibia from OVX+BZA mice had greater cortical cross-sectional area and moment of inertia than OVX mice treated with placebo (p<0.001), but there was no impact of BZA treatment on cortical bone mineral density, cortical thickness, tibial bone ultimate load or stiffness (p≥0.086). Overall, these results indicate that BZA may be an estrogen receptor agonist in skeletal muscle, as it has previously been shown in bone, providing minor benefits to the musculoskeletal system.

 

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