Soy isoflavones recovers pancreatic islet function and prevents metabolic dysfunction in male rats

in Journal of Endocrinology
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  • 1 T Ribeiro, Department of Cell Biology and Genetics, State University of Maringá, Maringá, Brazil
  • 2 A Pavanello, Department of Cell Biology and Genetics, State University of Maringá, Maringá, Brazil
  • 3 L Tófolo, Department of Cell Biology and Genetics, State University of Maringá, Maringá, Brazil
  • 4 J de Oliveira, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil
  • 5 A Moraes, Department of Biotechnology, Genetics and Cell Biology, Universidade Estadual de Maringa, Maringa, Brazil
  • 6 C Franco, Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil
  • 7 K Prates, Department of Cell Biology and Genetics, Universidade Estadual de Maringa, Maringa, Brazil
  • 8 I Martins, Department of Biotechnology, Genetics and Cell Biology, Universidade Estadual de Maringa, Maringa, Brazil
  • 9 K Palma-Rigo, Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil
  • 10 R Torrezan, Department of Physiological Sciences, State University of Maringá, Maringá, Brazil
  • 11 E Yeo, Department Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Canada
  • 12 R Gomes, Departamento de Ciências Fisiológicas, Universidade Estadual de Maringá, Maringá, Brazil
  • 13 F Francisco, Department of Cell Biology and Genetics, State University of Maringá, Maringá, Brazil
  • 14 P Mathias, Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, Brazil
  • 15 A Malta, Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá Maringá, Maringá, Brazil

Correspondence: Ananda Malta, Email: nandamalt@hotmail.com
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We tested whether chronic supplementation with soy isoflavones could modulate insulin secretion levels and subsequent recovery of pancreatic islet function as well as prevent metabolic dysfunction induced by early overfeeding in adult male rats. Wistar rats raised in small litters (SL, 3 pups/dam) and normal litters (NL, 9 pups/dam) were used as models of early overfeeding and normal feeding, respectively. At 30 to 90 days old, animals in the SL and NL groups received either soy isoflavones extract (ISO) or water (W) gavage serving as controls. At 90 days old, body weight, visceral fat deposits, glycemia, insulinemia were evaluated. Glucose-insulin homeostasis and pancreatic-islet insulinotropic response were also determined.

The early life overnutrition induced by small litter displayed metabolic dysfunction, glucose and insulin homeostasis disruption in adult rats. However, adult SL rats treated with soy isoflavones showed improvement in glucose tolerance, insulin sensitivity, insulinemia, fat tissue accretion and body weight gain, compared with SL-W group. Pancreatic-islet response to cholinergic, adrenergic and glucose stimuli was improved in both isoflavone-treated groups. In addition, different isoflavone concentrations increased glucose-stimulated insulin secretion in islets of all groups with higher magnitude in both NL and SL isoflavone treated groups. These results indicate that long-term treatment with soy isoflavones inhibits early overfeeding-induced metabolic dysfunction in adult rats and modulated the process of insulin secretion in pancreatic islets.

 

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