Regulation of adipose tissue development and energy metabolism by VEGFB isoforms

in Journal of Endocrinology
Authors:
Yang ChenY Chen, School of Life Sciences, Xuzhou Medical University, Xuzhou, 221004, China

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Xin LiX Li, School of Life Sciences, Xuzhou Medical University, Xuzhou, China

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Jing ZhangJ Zhang, School of Life Sciences, Northeast Normal University, Changchun, China

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Mingjiao ZhangM Zhang, Tansgenic Research Center, Northeast Normal University, Changchun, China

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Salah AdlatS Adlat, School of Life Sciences, Northeast Normal University, Changchun, China

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Xiaodan LuX Lu, School of Life Sciences, Northeast Normal University, Changchun, China

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Dan LiD Li, School of Life Sciences, Northeast Normal University, Changchun, China

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Honghong JinH Jin, School of Life Sciences, Northeast Normal University, Changchun, China

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Chenhao WangC Wang, Tansgenic Research Center, Northeast Normal University, Changchun, China

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Zin Mar OoZ Oo, School of Life Sciences, Northeast Normal University, Changchun, China

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Farooq HayelF Hayel, School of Life Sciences, Northeast Normal University, Changchun, China

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Quangang ChenQ Chen, School of Life Sciences, Xuzhou Medical University, Xuzhou, China

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Xufeng HanX Han, School of Life Sciences, Xuzhou Medical University, Xuzhou, China

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Renjin ChenR Chen, School of Life Sciences, Xuzhou Medical University, Xuzhou, China

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Xuechao FengX Feng, transgenic animal center, Northeast Normal University, Changchun, China

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Luqing ZhangL Zhang, School of Life Sciences, Northeast Normal University, Changchun, China

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Yaowu ZhengY Zheng, Transgenic Research Center, Northeast Normal University, Changchun, China

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Correspondence: Yaowu Zheng, Email: zhengyw442@nenu.edu.cn
DOI:
https://doi.org/10.1530/JOE-22-0329
Volume/Issue:
Accepted Manuscripts
Article Type:
Research Article
Article ID:
JOE-22-0329
Online Publication Date:
01 Apr 2023
Copyright:
© 2023 Society for Endocrinology 2023
Restricted access

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Obesity is caused by imbalanced energy intake and expenditure. The excessive energy intake and storage in adipose tissues is associated with many diseases. Several studies have demonstrated that VEGFB deficiency induces obese phenotypes. However, roles of VEGFB isoforms VEGFB167 and VEGFB186 in adipose tissue development and function are still not clear. In this study, genetic mouse models of adipose-specific VEGFB167 and VEGFB186 overexpression (aP2-Vegfb167tg/+ and aP2-Vegfb186tg/+) were generated and their biologic roles were investigated. On regular chow, adipose-specific VEGFB186 is negatively associated with white adipose tissues (WAT) and positively regulates brown adipose tissues (BAT). VEGFB186 up-regulates energy metabolism and metabolism-associated genes. In contrast, VEGFB167 has nominal roles in adipose development and function. On high fat diet, VEGFB186 expression can reverse the phenotypes of VEGFB deletion. VEGFB186 overexpression up-regulates BAT-associated genes and down-regulates WAT-associated genes. VEGFB186 and VEGFB167 have very distinct roles in regulation of adipose development and energy metabolism. As a key regulator of adipose tissue development and energy metabolism, VEGFB186 may be a target for obesity prevention and treatment.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© 2023 Society for Endocrinology 2023
Article ID:
JOE-22-0329
Article Type:
Research Article
Received Date:
16 Aug 2022
Rev-recd:
18 Apr 2023
Accepted Date:
19 Apr 2023
Print Publication Date:
Apr 2023
Online Publication Date:
01 Apr 2023