Sex Effects in Endocrine Health and Disease

In recent years, the importance of studying both males and females in model systems and humans has been brought sharply into focus and is now an expected part of experimental medicine. The field of personalised medicine remains limited due to many therapies and disease insights being based on trials involving only one sex. Therefore, this collection aims to showcase the importance of studying both sexes in translational endocrinology, specifically in the field of metabolic homeostasis across the life- and health-spans. 

Welcome for submission are studies which highlight both convergent and divergent responses in males and females, focussing on basic and translational science. 

Topic of interest include:

• the differences in metabolic responses between males and females
• the contribution of sex hormones to maintaining health across the lifecourse in both sexes
• sex differences in glucose metabolism
• influence of sex on cardiovascular diseases
• sex effects on energy balance/body weight regulation and CNS signalling
• the interplay between androgens and oestrogens in metabolic health and disease in both sexes
• insights into complex responses in metabolic homeostasis during sex hormone therapy (e.g. fertility regulation, replacement and gender reassignment).

Contribute to this important field of research by submitting an article. 

We encourage submissions which explore in vivo models, both mammalian and also models systems (e.g. zebrafish). Cell and organoid studies which advance mechanistic understanding of shared or sex-specific responses are most welcome, as are computational investigations. 

Review articles are also welcome but should be submitted alongside a brief review proposal as a supplemental file. This should include:

• a brief explanation of why the topic would be of interest to Journal of Endocrinology or Journal of Molecular Endocrinology readers
• 2–3 key publications from your research group which highlight expertise within the field.

For more information and to submit your proposal, please email joe@bioscientifica.com.

Published Articles:

Deletion of Hsd11b1suppresses caloric restriction-induced bone marrow adiposity in male but not female mice
Andrea Lovdel, Karla J Suchacki, Fiona Roberts, Richard J Sulston, Robert J Wallace, Benjamin J Thomas, Rachel M B Bell, Iris Pruñonosa Cervera, Gavin J Macpherson, Nicholas M Morton, Natalie Z M Homer, Karen E Chapman, and William P Cawthorn

Collection Editors