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Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
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Research Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA
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University of Colorado Denver – Anschutz Medical Campus, Denver, Colorado, USA
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Kansas City VA Medical Center, Kansas City, Missouri, USA
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Research Service-Harry S Truman Memorial VA Hospital, Columbia, Missouri, USA
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Department of Child Health, University of Missouri, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
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adversely affect brown adipocyte insulin sensitivity and contribute to systemic insulin resistance, whereas FGF21 and exercise may both improve systemic insulin sensitivity by mitigating inflammation in WAT and BAT. Indeed, we found that exercise reduced BAT
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morphological features. Mesenchymal precursor cells can produce white adipocytes, acting as a store of energy in the form of lipids, under conditions of excess calories, while Myf5-expressing precursor cells yield brown adipocytes, which are major site of non
Department of Pharmacology, School of Biomedical Sciences, UNSW Sydney, New South Wales, Australia
Department of Cellular and Molecular Medicine, Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Charles Perkins Centre, University of Sydney, New South Wales, Australia
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Department of Anatomy & Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia
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Charles Perkins Centre, University of Sydney, New South Wales, Australia
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Department of Pharmacology, School of Biomedical Sciences, UNSW Sydney, New South Wales, Australia
Cellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
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2005 SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes . Journal of Biological Chemistry 280 13560 – 13567 . ( https://doi.org/10.1074/jbc.M414670200 ) Shimazu T Hirschey MD Hua L
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formation for normal physiological function ( Cortes & Fernandez-Galilea 2015 ). In contrast to white adipocytes, brown adipose tissue (BAT) is specialised for heat generation by non-shivering thermogenesis. Brown adipocytes, unlike white adipocytes, have
Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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and brown adipocyte gene expression profiles. Figure 4 CR-induced activation of BAT and browning of WAT in female Ins2 − / − mice. Body composition; n = 13–21 (A and B), representative pictures of fat composition, magnified
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( Nobre et al. 2012 , 2016 ). In addition, Malloy & Feldman (2013) showed that VDR, in the absence of the ligand, inhibits UCP1 expression in human brown adipocytes, suggesting a reduced thermogenic capacity in vitamin D deficiency. Taken together
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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. Hormone Research in Paediatrics 79 83 – 87 . ( doi:10.1159/000346898 ) Rodríguez-Cuenca S Monjo M Gianotti M Proenza AM Roca P 2007 Expression of mitochondrial biogenesis-signaling factors in brown adipocytes is influenced specifically by
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The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia
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The University of Sydney, School of Medical Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia
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, G , H and I ). There was an expected decrease in protein content in the BAT of HFD-fed mice and mice held at 29°C, which is likely due to an increase in stored lipid ( Fig. 3J ). H & E staining of the BAT displayed classical brown adipocytes with
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Department of Minimally Invasive Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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KIIT School of Biotechnology, KIIT University, Bhubaneswar, India
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. 2014 ). These differences in thermogenesis were not associated with the increased levels of brown adipocytes, since the expression of brown adipose tissue (BAT) marker Prdm16 was similar between groups ( Fig. 5F ). Although Ucp1 expression was
Department of Functional Genomics, University of Science and Technology, Daejeon, Republic of Korea
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Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea
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Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea
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Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
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B Wahli W 2004 Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse . PNAS 101 4543 – 4547 . ( doi:10.1073/pnas.0400356101 ) 10.1073/pnas.0400356101 Jia L