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Saleela M Ruwanpura Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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Robert I McLachlan Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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Sarah J Meachem Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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executioner caspases 3, 6, and 7 causing apoptosis. The ER pathway involves the activation of caspase 12 and subsequent activation of executioner caspases. The crosstalk between these pathways occurs at multiple levels. Crosstalk between apoptotic pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0025
Volume/Issue:
Volume 205: Issue 2
Free access
Soo-Hyun Kim
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Jeremy Turnbull Division of Biomedical Sciences, Institute of Integrative Biology, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Scott Guimond Division of Biomedical Sciences, Institute of Integrative Biology, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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in ECM through the crosstalk between integrins and the actin cytoskeleton. Integrins are heterodimeric transmembrane receptors composed of eighteen α subunits and eight β subunits that can be non-covalently assembled into 24 combinations. The integrin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0377
Volume/Issue:
Volume 209: Issue 2
Free access
Jennifer J DuPont Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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Iris Z Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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SMC. Further, Lemariè and coworkers demonstrated that aldosterone-induced activation of SMC signaling pathways such as ERK1/2, JNK and NF-kB require a functional AT1R ( Lemariè et al. 2009 ). The precise mechanisms of the crosstalk between AT1R and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0009
Volume/Issue:
Volume 234: Issue 1
Free access
R L Moore Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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Y Dai Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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D V Faller Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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hormone receptor activation ( Dillon et al . 2007 , Wang et al . 2007 ), generating a positive-feedback loop. In the case of prostate cancer cells, the AR-signaling pathway and the PI 3 K/AKT pathway cross-talk through FOXO proteins, among other routes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0217
Volume/Issue:
Volume 213: Issue 1
Free access
Marco Hatem-Vaquero Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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Mercedes Griera Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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Andrea García-Jerez Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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Alicia Luengo Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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Julia Álvarez Endocrinology and Nutrition Department, Hospital Príncipe de Asturias, Madrid, Spain

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José A Rubio Endocrinology and Nutrition Department, Hospital Príncipe de Asturias, Madrid, Spain

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Laura Calleros Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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Diego Rodríguez-Puyol Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain
Biomedical Research Foundation and Nephrology Department, Hospital Príncipe de Asturias, Madrid, Spain
Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain

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Manuel Rodríguez-Puyol Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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Sergio De Frutos Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain
Instituto Reina Sofía de Investigación Renal and REDinREN from Instituto de Salud Carlos III, Madrid, Spain

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WAT compared with striated muscle ( Shepherd & Kahn 1999 ), it has been reported that specific reduction of GLUT4 protein levels in WAT may affect glucose homeostasis regulated by the crosstalk between WAT and striated muscle leading to an impairment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0662
Volume/Issue:
Volume 234: Issue 2
Free access
Jennifer A Crookshank Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Daniel Serrano Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Gen-Sheng Wang Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Christopher Patrick Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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Baylie S Morgan Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biomedical Sciences, University of Ottawa, Ottawa, Ontario, Canada

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Marie-France Paré Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Fraser W Scott Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

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-diabetes-prone (BBc) and BBdp rats at age ~8, 30 and 60 days. Differences in gene expression in both pancreas and liver of prediabetic individuals suggested that diabetogenesis begins very early in the pancreas and may involve crosstalk with other organs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0328
Volume/Issue:
Volume 239: Issue 2
Free access
Melanie Tran Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Golam Mostofa Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Michael Picard Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Jianguo Wu Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Li Wang Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

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Dong-Ju Shin Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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deterioration of insulin sensitivity, providing the pathophysiological mechanism underlying the development of NAFLD ( Byrne & Targher 2015 , Friedman et al. 2018 ) . A wealth of data have demonstrated metabolic crosstalk between adipose tissue and liver

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0073
Volume/Issue:
Volume 256: Issue 3
Restricted access
Eliane Correa-de-Santana
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Bianca Fröhlich
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Marta Labeur
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Marcelo Páez-Pereda Department of Endocrinology, Affectis Pharmaceuticals, Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Marily Theodoropoulou
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Jose Luis Monteserin
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Ulrich Renner
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Günter K Stalla
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transcriptional activity after activation of the NOD2 receptor. Thus, MDP stimulation and NOD2 overexpression result in the synthesis and activation of STAT3 in TtT/GF cells. Whether IL6 mediates the stimulation of STAT3 is currently under investigation. Cross-talk

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0113
Volume/Issue:
Volume 203: Issue 1
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Cathy A Guo Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

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Shaodong Guo Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

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together, we believe that targeting mitochondrial biogenesis and metabolism would provide a powerful strategy to prevent or treat heart failure in the future. Crosstalk between insulin signaling and renin–angiotensin system via Foxo1 Currently, the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0679
Volume/Issue:
Volume 233: Issue 3
Free access
Tian Shuang Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada
School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
Department of Biology, Laurentian University, Ontario, Canada

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Ming Fu Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada
School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
Health Sciences North Research Institute, Sudbury, Ontario, Canada

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Guangdong Yang Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada
Department of Chemistry and Biochemistry, Laurentian University, Ontario, Canada

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Ying Huang Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada
School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada

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Zhongming Qian Nantong University, Nantong, Jiangsu, China

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Lingyun Wu Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada
School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
Health Sciences North Research Institute, Sudbury, Ontario, Canada

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Rui Wang Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada
Department of Biology, Laurentian University, Ontario, Canada
Department of Biology, York University, Toronto, Ontario, Canada

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biological processes are regulated by crosstalk among multiple signaling pathways. IGF-1, acting mainly on IGF-1R, induces activation and phosphorylation of ER in uterine cells ( Aronica & Katzenellenbogen 1993 ). The interaction between IGF-1R and ER results

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0190
Volume/Issue:
Volume 248: Issue 1
Restricted access