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P Froment INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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F Gizard INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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D Defever INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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B Staels INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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J Dupont INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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P Monget INSERM U.418, UMR Communications Cellulaire et Différenciation, Hôpital Debrousse, 29 rue Soeur Bouvier, 69322 Lyon, France
INSERM U.545, Institut Pasteur de Lille et Faculté de Pharmacie Université de Lille 2, 1 rue du Pr Calmette, 59019 Lille, France
LMCB, Department of Molecular Biomedical Research, V.I.B., Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium
Physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours-Haras Nationaux, 37380 Nouzilly, France

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strongly expressed during decidualization, and regulates embryo implantation ( Lim & Dey 2000 , 2002 ). PPARβ/δ is found around implantation sites, and PPARβ/δ-null mice present placental malformations leading to embryo death during early pregnancy ( Barak

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Karen Forbes School of Biomedicine, Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9WL, UK

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Melissa Westwood School of Biomedicine, Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9WL, UK

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placenta ( Fig. 1 ), cytotrophoblasts are a progenitor stem cell population which continuously proliferate and differentiate into one of two subtypes; extravillous trophoblasts that migrate into the maternal decidualized endometrium and remodel the spiral

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Alison E Wallace MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Douglas A Gibson MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Philippa T K Saunders MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Henry N Jabbour MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Expression of interleukin-11 during the human menstrual cycle: coincidence with stromal cell decidualization and relationship to leukaemia inhibitory factor and prolactin . Molecular Human Reproduction 6 907 – 914 . Doll A Abal M Rigau M Monge M

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Adam Hagg School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Eliza O’Shea School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Craig A Harrison Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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Kelly L Walton School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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://doi.org/10.1073/pnas.83.10.3091 ) Fullerton PT Jr Monsivais D Kommagani R & Matzuk MM 2017 Follistatin is critical for mouse uterine receptivity and decidualization . Proceedings of the National Academy of Sciences of the United States of America

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Daniel J Tobiansky Department of Psychology, The University of British Columbia
Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada

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George V Kachkovski Department of Psychology, The University of British Columbia

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Reilly T Enos Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA

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Kim L Schmidt Department of Psychology, The University of British Columbia

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E Angela Murphy Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA

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Kiran K Soma Department of Psychology, The University of British Columbia
Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada
Department of Zoology, The University of British Columbia, Vancouver, British Columbia, Canada

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A Scheaffer S Moley KH 2016 Excess maternal fructose consumption increases fetal loss and impairs endometrial decidualization in mice . Endocrinology 157 956 – 968 . ( https://doi.org/10.1210/en.2015-1618 ) Schindelin J Arganda

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Sophie A Clarke Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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Waljit S Dhillo Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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M Zhong T Lin Y Zong T Zhong C Zhang B Ren M Kuang H 2014 Expression and function of kisspeptin during mouse decidualization . PLoS ONE 9 e97647 . ( doi:10.1371/journal.pone.0097647 )

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Josephine F Trott Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA
Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Katherine C Horigan Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Julia M Gloviczki Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA
Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Kristen M Costa Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Bradley A Freking Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Chantal Farmer Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Kanako Hayashi Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Thomas Spencer Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Joseph E Morabito Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Russell C Hovey Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA
Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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. Journal of Biological Chemistry 274 37982 – 37989 . Reese J Binart N Brown N Ma WG Paria BC Das SK Kelly PA Dey SK 2000 Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but

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Esther Dos Santos Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Marie-Noëlle Dieudonné Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Marie-Christine Leneveu Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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René Pecquery Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Valérie Serazin Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Yves Giudicelli Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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. Kasahara K , Takakura K, Takebayashi K, Kimura F, Nakanishi K & Noda Y 2001 The role of human chorionic gonadotropin on decidualization of endometrial stromal cells in vitro . Journal of Clinical Endocrinology and Metabolism 86 1281 –1286

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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stromal cell decidualization . Biology of Reproduction 104 336 – 343 . ( https://doi.org/10.1093/biolre/ioaa211 ) Chen L Li Q Zheng D Jiang H Wei Y Zou L Feng L Xiong G Sun G Wang H , 2020a Clinical characteristics of pregnant women

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