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Yingning Ji
Yingning Ji
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Wei Liu
Wei Liu
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China
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Yemin Zhu
Yemin Zhu
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yakui Li
Yakui Li
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Ying Lu
Ying Lu
Department of Biochemistry and Molecular Biology of School of Basic Medical College of Fudan University, Shanghai, China
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Qi Liu
Qi Liu
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Lingfeng Tong
Lingfeng Tong
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Lei Hu
Lei Hu
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Nannan Xu
Nannan Xu
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Zhangbing Chen
Zhangbing Chen
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Na Tian
Na Tian
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
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Lifang Wu
Lifang Wu
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Lian Zhu
Lian Zhu
Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shuang Tang
Shuang Tang
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China
Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China
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Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China
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Ping Zhang
Ping Zhang
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xuemei Tong
Xuemei Tong
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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prior to STZ injection, and 10% sucrose water was supplied overnight after the first injection to avoid sudden hypoglycemia. Western blotting analysis Total protein was extracted from tissues using cell lysis buffer for Western blot and IP
Youichi Sato
Youichi Sato
Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1 Sho-machi, Tokushima City 770-8505 Japan
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Takanobu Kamada
Takanobu Kamada
Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1 Sho-machi, Tokushima City 770-8505 Japan
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Aiko Yamauchi
Aiko Yamauchi
Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1 Sho-machi, Tokushima City 770-8505 Japan
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inhibitors are considered to be useful as anti-diabetic agents that result in a low incidence of hypoglycemia and minimal weight gain ( Nielsen 2005 , Green et al . 2006 , Hinnen et al . 2006 , Kendall et al . 2006 ). DPP4 inhibitors have been shown to
Lucia Gajdosechova
Lucia Gajdosechova
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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Katarina Krskova
Katarina Krskova
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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Ana Belen Segarra
Ana Belen Segarra
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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Andrea Spolcova
Andrea Spolcova
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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Maciej Suski
Maciej Suski
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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Rafal Olszanecki
Rafal Olszanecki
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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Stefan Zorad
Stefan Zorad
Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia
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.1038/oby.2009.12 ) Coiro V Passeri M Davoli C d'Amato L Gelmini G Fagnoni F Schianchi L Bentivoglio M Volpi R Chiodera P 1988 Oxytocin response to insulin-induced hypoglycemia in obese subjects before and after weight loss . Journal
Antonella Amato
Antonella Amato
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Sara Baldassano
Sara Baldassano
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Rosa Liotta
Rosa Liotta
Laboratorio di Fisiologia Generale, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy
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Rosa Serio
Rosa Serio
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Flavia Mulè
Flavia Mulè
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fasting hypoglycemia in SUR-1−/− mice by lowering cAMP in pancreatic β-cells and inhibiting insulin secretion . Journal of Biological Chemistry 283 25786 – 25793 . ( doi:10.1074/jbc.M804372200 ) Delgado-Aros S Kim DY Burton DD Thomforde GM
Casey D Wright
Casey D Wright
Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
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Ryan J Orbus
Ryan J Orbus
Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
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Timothy R H Regnault
Timothy R H Regnault
Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
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Russell V Anthony
Russell V Anthony
Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
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Animal Reproduction and Biotechnology Laboratory, Department of Pediatrics, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA
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fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells . American Journal of Physiology 292 E1256 – E1264 . Spencer TE Gray A Johnson GA Taylor KM Gertler A Gootwine E Ott TL Bazer FW 1999
Masaru Koizumi
Masaru Koizumi
Division of Integrative Physiology, Department of Surgery, Department of Physiology
Division of Integrative Physiology, Department of Surgery, Department of Physiology
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Division of Integrative Physiology, Department of Surgery, Department of Physiology
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Toshihiko Yada
Toshihiko Yada
Division of Integrative Physiology, Department of Surgery, Department of Physiology
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S Inouye K Shum K Matthews SG Vranic M 2002 Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses . Diabetes 51 1681 – 1689 . Dallman MF Akana
Tao Xie
Tao Xie
Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
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Min Chen
Min Chen
Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
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Lee S Weinstein
Lee S Weinstein
Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
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hypoglycemia in mice with liver-specific G s α deficiency . Journal of Clinical Investigation 115 3217 – 3227 . Ding WG Renstrom E Rorsman P Buschard K Gromada J 1997 Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide
Andreas Nygaard Madsen
Andreas Nygaard Madsen
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Gitte Hansen
Gitte Hansen
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Sarah Juel Paulsen
Sarah Juel Paulsen
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Kirsten Lykkegaard
Kirsten Lykkegaard
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Mads Tang-Christensen
Mads Tang-Christensen
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Harald S Hansen
Harald S Hansen
Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark
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Barry E Levin
Barry E Levin
Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark
Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark
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Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark
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Philip Just Larsen
Philip Just Larsen
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Lotte Bjerre Knudsen
Lotte Bjerre Knudsen
Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark
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Keld Fosgerau
Keld Fosgerau
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Niels Vrang
Niels Vrang
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preexisting defects in their counterregulatory response to insulin-induced hypoglycemia . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 287 R1110 – R1115 . Zinman B Gerich J Buse JB Lewin A Schwartz S Raskin
Toya M Albury-Warren
Toya M Albury-Warren
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
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Veethika Pandey
Veethika Pandey
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
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Lina P Spinel
Lina P Spinel
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
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Michal M Masternak
Michal M Masternak
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
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Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
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Deborah A Altomare
Deborah A Altomare
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
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rat insulin promoter (RIP), led to hypoglycemia, hyperinsulinemia and improved glucose tolerance, due to increased β-cell mass, size, and proliferation. We recently characterized aged mice with myristoylated, membrane-bound Akt1 (AKT1 Myr ) expressed
Martina Bugáňová
Martina Bugáňová
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic
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Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic
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Helena Pelantová
Helena Pelantová
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Martina Holubová
Martina Holubová
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Blanka Šedivá
Blanka Šedivá
Faculty of Applied Sciences, University of West Bohemia, Plzeň, Czech Republic
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Lenka Maletínská
Lenka Maletínská
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Blanka Železná
Blanka Železná
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Jaroslav Kuneš
Jaroslav Kuneš
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Petr Kačer
Petr Kačer
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic
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Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic
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Marek Kuzma
Marek Kuzma
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Martin Haluzík
Martin Haluzík
Centre for Experimental Medicine and Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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-established therapeutic agents including antidiabetic therapies. Incretin-based therapies represent one of the most promising approaches in T2DM treatment owing to good efficacy and the fact that they do not have major side effects such as hypoglycemia and weight gain
