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Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada
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Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada
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Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada
Department of Zoology, The University of British Columbia, Vancouver, British Columbia, Canada
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Litwan K Krämer SD Ametamey SM Schibli R Wolfrum C 2016 Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition . Translational Psychiatry 6 e911 – e911 . ( https://doi.org/10.1038/tp.2016.176 ) Pinheiro
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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and female pups were cross-fostered and reared in two different litter sizes: small litters (SLs: 4 pups per litter; as a model of postnatal overnutrition) or normal litters (NLs: 12 pups per litter), as extensively described previously ( Castellano
Argentine Research Council (CONICET), La Plata, Buenos Aires, Argentina
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Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
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/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity . Cell 135 61 – 73 . ( https://doi.org/10.1016/j.cell.2008.07.043 ) 18854155 10.1016/j.cell.2008.07.043
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overnutrition to energy imbalance and obesity . Cell 135 61 – 73 . ( doi:10.1016/j.cell.2008.07.043 ) This paper is one of four papers that form part of a thematic review section on Energy, Insulin Resistance and Metabolic Syndrome. The Guest Editor for this
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act in the brain to reduce food intake ( Woods et al . 1979 , Bruning et al . 2000 , Benedict et al . 2008 ). In obesity and over-nutrition, peripheral insulin resistance results in chronic hyperinsulinaemia. Interestingly, a study using 18-fluoro
Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK
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Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK
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states. Conclusion This current review has examined the importance of inflammatory pathways that can impact on adipokine function leading to insulin resistance. It is clear that through ‘overnutrition’, glucose, lipids and endotoxin can affect different
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during HFD-feeding ( Gautheron et al. 2016 , Afonso et al. 2021 ). A recent study established a role for RIPK3 in mediating IL-1β-dependent macrophage infiltration and β-cell dysfunction in response to ER stress or overnutrition, and inhibition of
Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany
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Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany
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formation of new vasculature ( Crewe et al. 2017 ). Under over-nutrition stress, adipocytes release pro-angiogenic and pro-inflammatory factors such as MCP1, TNFα, IL6, ICAM1, VCAM1, etc., which further increase inflammation by activating and recruiting
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( Zhu et al. 2015 ). While NAFLD most commonly refers to fatty liver resulting from overnutrition and consumption of a western diet, NAFLD may also be induced by endocrine disorders, viral infections or side effects of pharmacological therapies. The
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-1339 ) 10.2337/diabetes.55.04.06.db05-1339 16567519 Collden G Balland E Parkash J Caron E Langlet F Prevot V Bouret SG 2015 Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin . Molecular Metabolism 4 15