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found at baseline a low TRβ/TRα1 ratio in TRAMP. The high T 3 dose increased this ratio two-fold in WT and four-fold in TRAMP. Figure 3 Expression and immunolocalization of thyroid hormone receptors. (A) mRNA levels of TRα1 and TRβ were
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-mediated growth arrest has been observed in different cell lines including rat chondrocyte primary culture ( Ballock et al. 2000 ), murine neuroblastoma N2a-β cells that overexpress the thyroid hormone receptor β 1 isoform ( Perez-Juste & Aranda 1999
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thyroid hormone receptors β and α1 in regulation of type 1 deiodinase expression. Molecular Endocrinology 15 467 –475. Anderson GW , Mariash CN & Opperheimer JH 2000 Thyroid hormone action. In Werner and Ingbar’s The
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Endocrinology 105 39 –46. Chassande O 2003 Do unliganded thyroid hormone receptors have physiological functions? Journal of Molecular Endocrinology 31 9 –20. Choksi NY , Jahnke GD, St Hilaire C
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rats suggest that the downregulation of AQP8 by T3 may well be due to a T3-dependent interaction of thyroid hormone receptor with putative negative thyroid hormone response elements (nTRE; Crone et al. 1990 ) contained in the AQP8 promoter. This
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(ACTR), AIB-I, CBP interacting protein). Conversely, corepressors such as silencing mediator for retinoid and thyroid hormone receptor (SMRT) interact strongly with nuclear receptors under basal conditions and this interaction is thought to be
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2011 Thyroid Hormone Receptor beta (THRB) is a major target gene for microRNAs deregulated in Papillary Thyroid Carcinoma (PTC) . Journal of Clinical Endocrinology and Metabolism 96 546 – 553 . ( doi:10.1210/jc.2010-1594 ) 10.1210/jc.2010
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bovine embryo development in vitro ( Aghajanova et al . 2011 , Costa et al . 2013 ). In vivo , thyroid hormone receptor (TR) and thyrotropin receptor are expressed in the endometrium, and their expression in endometrial cells is concomitant with the
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MM Gigena N Donadio AC Blidner AG Milotich SI Cheng SY Masini-Repiso AM Rabinovich GA 2015 Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor beta
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-CoA synthetases . PNAS 103 10230 – 10235 . ( doi:10.1073/pnas.0604392103 ) Hashimoto K Curty FH Borges PP Lee CE Abel ED Elmquist JK Cohen RN Wondisford FE 2001 An unliganded thyroid hormone receptor causes severe neurological dysfunction