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A Fratticci Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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F A Grieco Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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C Spilioti Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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F Giangaspero Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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L Ventura Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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V Esposito Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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M Piccirilli Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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A Santoro Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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A Gulino Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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G Cantore Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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E Alesse Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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M L Jaffrain-Rea Department of Experimental Medicine, University of L’Aquila, Via Vetoio, Coppito 2 - 67100 L’Aquila (AQ), Italy
Neuromed Institute, IRCCS, Pozzilli, Via Atinense 18, 86077 Pozzilli (IS), Italy
Department of Experimental Medicine and Pathology, University ‘La Sapienza’, Policlinico Umberto 1°, Viale dell’Università, 00161 Rome (RM), Italy
Pathology, S Salvatore Hospital, L’Aquila, Coppito, 67 100 L’Aquila (AQ), Italy
Departments of Neurological Sciences, Policlinico Umberto 1°, Via Regina Margherita, 00161 Roma (RM), Italy
Fondazione ‘Carlo Ferri’, Via E. Riva 42, 00015 Monterotondo (RM), Italy

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Introduction Basic helix-loop-helix (bHLH) transcription factors play a fundamental role in the ontogenesis of highly differentiated cells, especially during neurogenesis, myogenesis and haemopoiesis ( Massari & Murre 2000 ), and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0020
Volume/Issue:
Volume 194: Issue 3
Free access
Robert Opitz Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Achim Trubiroha Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Claudia Lorenz Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Ilka Lutz Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Sabine Hartmann Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Tobias Blank Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Thomas Braunbeck Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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Werner Kloas Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D-12587 Berlin, Germany
Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany
Department of Endocrinology, Institute of Biology, Humboldt University, D-10115 Berlin, Germany

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( Saito et al. 1997 a , Ohno et al. 1999 , Trapasso et al. 1999 ). Three different transcription factors, including the paired box gene Pax8, the homeo-domain-containing protein Nkx2.1 (also called TTF-1 for thyroid transcription factor 1) and the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06606
Volume/Issue:
Volume 190: Issue 1
Free access
Yujiao Dai School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Peng Hao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhimei Sun School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Zhiyi Guo School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Hong Xu School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China

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Lihui Xue Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Hongyu Song Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Yida Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Shuang Li Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China

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Mingming Gao School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Teng Si School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China

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Yuxin Zhang School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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Yajuan Qi School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China
Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China
Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China

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potentially reverse hepatic fibrosis ( Mannaerts et al. 2015 ). As a coactivator of transcription factors, YAP promotes cell proliferation and inhibits apoptosis through the interaction between its transcriptional coactivator activity and TEAD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0561
Volume/Issue:
Volume 249: Issue 2
Restricted access
Andrew T Major Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Katie L Ayers Murdoch Childrens Research Institute, Royal Children’s Hospital and University of Melbourne Departments of Paediatrics, Royal Children’s Hospital, Parkville, Victoria, Australia

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Justin Chue Murdoch Childrens Research Institute, Royal Children’s Hospital and University of Melbourne Departments of Paediatrics, Royal Children’s Hospital, Parkville, Victoria, Australia

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Kelly N Roeszler Murdoch Childrens Research Institute, Royal Children’s Hospital and University of Melbourne Departments of Paediatrics, Royal Children’s Hospital, Parkville, Victoria, Australia

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Craig A Smith Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Introduction The forkhead box (FOX) family of transcription factors are conserved developmental regulators, playing diverse roles in cell differentiation, apoptosis and tumorigenesis ( Brunet et al. 1999 , Schmidt et al. 2002 , Stahl et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0277
Volume/Issue:
Volume 243: Issue 3
Restricted access
Zuzana Saidak UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France

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Carole Le Henaff UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France

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Sofia Azzi UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France

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Caroline Marty UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France

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Pierre J Marie UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France
UMR‐1132 Inserm, Université Paris Diderot, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, France

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to the inhibition of glycogen synthase kinase 3β and decreased phosphorylation, stabilisation and subsequent translocation of β-catenin into the nucleus. This results in the binding of β-catenin to T-cell-specific transcription factor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0249
Volume/Issue:
Volume 223: Issue 1
Free access
Bethania Mongi-Bragato Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ezequiel Grondona Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Liliana del Valle Sosa Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Natacha Zlocowski Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ana Clara Venier Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Alicia Inés Torres Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Alexandra Latini Laboratório de Bioenergética e Estresse Oxidativo – LABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Campus Universitário, Córrego Grande, Florianópolis, Brasil

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Rodrigo Bainy Leal Departamento de Bioquímica e Programa de Pós-graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brasil

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Silvina Gutiérrez Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ana Lucía De Paul Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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, NF-κB was found to be up-regulated in human pituitary adenomas ( Chen et al . 2015 ), with its pharmacological inhibition reducing cell viability in the GH3 pituitary cell line ( Vender et al . 2008 ), the role of this key transcription factor in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0506
Volume/Issue:
Volume 245: Issue 2
Restricted access
L Lundholm Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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G Bryzgalova
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H Gao Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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N Portwood
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S Fält Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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K D Berndt Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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A Dicker Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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D Galuska Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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J R Zierath Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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J-Å Gustafsson Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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S Efendic
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K Dahlman-Wright Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

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A Khan
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estrogen receptors (ERs), ERα and ERβ ( Dahlman-Wright et al . 2006 ). ERs belong to the nuclear receptor family of ligand-activated transcription factors, and modulate the expression of target genes by binding either to classic estrogen response

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0192
Volume/Issue:
Volume 199: Issue 2
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Jennifer J DuPont Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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Iris Z Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston

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suppression of the miR-155 transcription is unclear; however, the promoter has several binding sites for transcription factors, including NF-kB and AP-1 ( Onyeagucha et al. 2013 ), which are known to interact with the MR to regulate gene transcription

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0009
Volume/Issue:
Volume 234: Issue 1
Free access
Jane A Mitchell Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Mark J Paul-Clark Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Graham W Clarke Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Shaun K McMaster Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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Neil Cartwright Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

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sequences encoding proteins homologous to toll ( Taguchi et al. 1996 , Medzhitov et al. 1997 , Rock et al. 1998 ). In another seminal publication, Medzhitov et al. (1997) showed that activation of a human TLR leads to activation of transcription

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JOE-07-0067
Volume/Issue:
Volume 193: Issue 3
Free access
Shin Tsunekawa Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Naoki Yamamoto Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Katsura Tsukamoto Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Yuji Itoh Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Yukiko Kaneko Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Toshihide Kimura Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Yoh Ariyoshi Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Yoshitaka Miura Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Yutaka Oiso Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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Ichiro Niki Department of Endocrinology and Diabetes, School of Medicine, Nagoya University, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd, 363 Shiosaki, Hokusei, Inabe, Mie 511-0406, Japan
Department of Pharmacology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan

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-requiring enzyme-1 (IRE-1α), X-box-binding protein-1 (XBP-1), RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK), activating transcription factor-4 (ATF-4), C/EBP-homologous protein (CHOP)) were examined by RT-PCR. The sequences of the specific

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0148
Volume/Issue:
Volume 193: Issue 1
Free access