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Marika Bogdani
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Angela M Henschel Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Sanjay Kansra Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Jessica M Fuller Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Rhonda Geoffrey Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Shuang Jia Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Mary L Kaldunski Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Scott Pavletich Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Simon Prosser Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Yi-Guang Chen Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Åke Lernmark Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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Martin J Hessner Pacific Northwest Diabetes Research Institute, The Max McGee National Research Center for Juvenile Diabetes, Department of Medicine, Department of Clinical Sciences, 720 Broadway, Seattle, Washington 98122, USA

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/threonine kinase activity 64 1.3×10 −8  GO molecular function Transcription regulator activity 125 6.6×10 −6  GO molecular function Zinc ion binding 159 1.7×10 −5  GO molecular function Transcription repressor activity 41 2.3×10 −5  KEGG pathway Wnt signaling 28

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0385
Volume/Issue:
Volume 216: Issue 2
Free access
Andrew T Major Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Katie L Ayers Murdoch Childrens Research Institute, Royal Children’s Hospital and University of Melbourne Departments of Paediatrics, Royal Children’s Hospital, Parkville, Victoria, Australia

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Justin Chue Murdoch Childrens Research Institute, Royal Children’s Hospital and University of Melbourne Departments of Paediatrics, Royal Children’s Hospital, Parkville, Victoria, Australia

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Kelly N Roeszler Murdoch Childrens Research Institute, Royal Children’s Hospital and University of Melbourne Departments of Paediatrics, Royal Children’s Hospital, Parkville, Victoria, Australia

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Craig A Smith Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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dysfunction and impaired folliculogenesis only postnatally ( Schmidt et al. 2004 , Uda et al. 2004 , Ottolenghi et al. 2005 ). For more extensive masculinisation, both Foxl2 and the R-SPO1/Wnt4/β-catenin pathways must be inactivated in embryonic XX

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0277
Volume/Issue:
Volume 243: Issue 3
Restricted access
Anna Cinkajzlová Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic

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Miloš Mráz Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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Martin Haluzík Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

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signaling pathway, which in adipocytes acts as a modulator of their development ( Farmer 2005 ) and contributes to insulin resistance by supporting AT expansion and lipid accumulation ( Fuster et al. 2015 , Aamir et al. 2020 ). In macrophages, Wnt

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0159
Volume/Issue:
Volume 252: Issue 1
Free access
Bethania Mongi-Bragato Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ezequiel Grondona Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Liliana del Valle Sosa Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Natacha Zlocowski Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ana Clara Venier Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Alicia Inés Torres Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Alexandra Latini Laboratório de Bioenergética e Estresse Oxidativo – LABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Campus Universitário, Córrego Grande, Florianópolis, Brasil

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Rodrigo Bainy Leal Departamento de Bioquímica e Programa de Pós-graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brasil

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Silvina Gutiérrez Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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Ana Lucía De Paul Universidad Nacional de Córdoba, Facultad de Ciencias Médicas, Centro de Microscopía Electrónica, Córdoba, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina

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-called SASP ( Coppe et al . 2008 , Kuilman and Peeper 2009 ). In this scenario, the nuclear factor kappa B (NF-κB) signalling pathway has been proposed to control SASP production ( Freund et al . 2011 , Salminen et al . 2012 ), with a causal role

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0506
Volume/Issue:
Volume 245: Issue 2
Restricted access
Peter J King
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Leonardo Guasti
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Ed Laufer Barts and the London School of Medicine, Department of Pathology and Cell Biology, Centre for Endocrinology, London EC1M 6BQ, UK

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, leads to abnormalities that overlap those seen in cases of impaired Hh signalling ( Kelley & Hennekam 2000 ). Signal transduction pathway Hh proteins bind 12 pass transmembrane receptors Patched1 (Ptch1) and Ptch2 on responding cells ( Fig. 1 ). Binding

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0161
Volume/Issue:
Volume 198: Issue 3
Free access
Markus Meier Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, D- 23538 Lübeck, Germany
Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany

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Harald H Klein Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, D- 23538 Lübeck, Germany
Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany

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Jan Kramer Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, D- 23538 Lübeck, Germany
Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany

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Maren Drenckhan Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, D- 23538 Lübeck, Germany
Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany

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Morten Schütt Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, D- 23538 Lübeck, Germany
Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany

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-lysosomal cytoplasmatic cysteine proteases that catalyze the endoproteolytic cleavage of specific substrates and thereby regulate pathways which affect intracellular signaling. Fourteen members of the calpain family have been identified so far, some of which are tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07087
Volume/Issue:
Volume 193: Issue 1
Free access
Haiming Cao National Heart, Lung and Blood Institute, National Institutes of Health, Center for Molecular Medicine, 10 Center Drive, Building 10, 8N109, MSC 1760, Bethesda, Maryland 20892, USA

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efforts to elucidate the pathophysiological mechanisms by which obesity induces or amplifies its major adverse consequences. The concept of an adipocytokine was developed in this process and dysfunction of adipocytokine pathways has been recognized as a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0339
Volume/Issue:
Volume 220: Issue 2
Free access
Erica Yeo Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada

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Patricia L Brubaker Department of Physiology, University of Toronto, Toronto, ON, Canada
Department of Medicine, University of Toronto, Toronto, ON, Canada

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Deborah M Sloboda Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada

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investigated these signaling pathways in the maternal L-cell during pregnancy, although genetic variants of TCF proteins (nuclear Wnt pathway components) have been associated with the development of GDM ( Shaat et al. 2007 , Reyes-López et al. 2014 ). But

Article Type:
Review Article
Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-21-0354
Volume/Issue:
Volume 253: Issue 1
Open access
Christoph Schmid Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland

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Marian C Neidert Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland

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Oliver Tschopp Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland

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Lisa Sze Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland
Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland

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René L Bernays Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland
Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland

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enhanced activation of the PI3K/PKB pathway ( Zhu et al . 2013 ). Functional loss of Klotho due to epigenetic silencing was found to promote tumour progression in a variety of cancers. Inhibition of Wnt signalling may play a role in the senescence

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0285
Volume/Issue:
Volume 219: Issue 2
Free access
Dario R Lemos Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of

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Jodi L Downs Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of

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Martin N Raitiere Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of

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Henryk F Urbanski Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of

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al . 2008 ). Furthermore, light itself exerts a remarkable effect on adrenal physiology; in mice, light exposure at night induces both gene expression and the secretion of corticosterone, through a pathway that involves the SCN and the sympathetic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0437
Volume/Issue:
Volume 201: Issue 2
Free access