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/threonine kinase activity 64 1.3×10 −8 GO molecular function Transcription regulator activity 125 6.6×10 −6 GO molecular function Zinc ion binding 159 1.7×10 −5 GO molecular function Transcription repressor activity 41 2.3×10 −5 KEGG pathway Wnt signaling 28
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dysfunction and impaired folliculogenesis only postnatally ( Schmidt et al. 2004 , Uda et al. 2004 , Ottolenghi et al. 2005 ). For more extensive masculinisation, both Foxl2 and the R-SPO1/Wnt4/β-catenin pathways must be inactivated in embryonic XX
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic
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Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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signaling pathway, which in adipocytes acts as a modulator of their development ( Farmer 2005 ) and contributes to insulin resistance by supporting AT expansion and lipid accumulation ( Fuster et al. 2015 , Aamir et al. 2020 ). In macrophages, Wnt
Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Ciencias de la Salud (INICSA), Córdoba, Argentina
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-called SASP ( Coppe et al . 2008 , Kuilman and Peeper 2009 ). In this scenario, the nuclear factor kappa B (NF-κB) signalling pathway has been proposed to control SASP production ( Freund et al . 2011 , Salminen et al . 2012 ), with a causal role
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, leads to abnormalities that overlap those seen in cases of impaired Hh signalling ( Kelley & Hennekam 2000 ). Signal transduction pathway Hh proteins bind 12 pass transmembrane receptors Patched1 (Ptch1) and Ptch2 on responding cells ( Fig. 1 ). Binding
Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany
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Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany
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Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany
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Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany
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Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, Bochum, Germany
Curschmann-Klinik, Timmendorfer Strand, Germany
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-lysosomal cytoplasmatic cysteine proteases that catalyze the endoproteolytic cleavage of specific substrates and thereby regulate pathways which affect intracellular signaling. Fourteen members of the calpain family have been identified so far, some of which are tissue
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efforts to elucidate the pathophysiological mechanisms by which obesity induces or amplifies its major adverse consequences. The concept of an adipocytokine was developed in this process and dysfunction of adipocytokine pathways has been recognized as a
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
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Department of Medicine, University of Toronto, Toronto, ON, Canada
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Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada
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investigated these signaling pathways in the maternal L-cell during pregnancy, although genetic variants of TCF proteins (nuclear Wnt pathway components) have been associated with the development of GDM ( Shaat et al. 2007 , Reyes-López et al. 2014 ). But
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Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland
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Division of Endocrinology and Diabetology, Department of Neurosurgery, Division of Endocrinology and Diabetology, Department of Neurosurgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland
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enhanced activation of the PI3K/PKB pathway ( Zhu et al . 2013 ). Functional loss of Klotho due to epigenetic silencing was found to promote tumour progression in a variety of cancers. Inhibition of Wnt signalling may play a role in the senescence
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Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
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Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
Division of Neuroscience, Physiology and Pharmacology, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA Departments of
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al . 2008 ). Furthermore, light itself exerts a remarkable effect on adrenal physiology; in mice, light exposure at night induces both gene expression and the secretion of corticosterone, through a pathway that involves the SCN and the sympathetic